First question: how much of this are you doing in Python?Are you simply calling out programmers Geoprocessing tools or are you doing computer technology huge amount of numeric analysis in Python?If programming former, programming bottlenecks likely live in programming tools and using native code in your script won’t buy you as much as any other clever workarounds. If programming latter, then you definately may want programmers find what’s slow and make it faster with better algorithms, or perhaps numpy, or another option as discussed below. py2exe doesn’t in fact compile your code programmers native x86/x64, it just adds an executable that embeds your script as bytecode and provides laptop science mostly portable way of distributing it programmers users without Python on their techniques. It failed when trying programmers bundle arcgisscripting, that’s why it did not work. Actually getting py2exe working still won’t do anything else functionality wise. I very strongly recommend you first use computer technology profiler programmers identify programming slow bits and optimize from there.